Free, personalized support for people with NF1-PN taking GOMEKLI (mirdametinib)

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GOMEKLI (mirdametinib) is a prescription medicine used to treat adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas (PN) that cause symptoms and cannot be completely removed by surgery.

It is not known if GOMEKLI is safe and effective in children under 2 years of age.

Please see Important Safety Information later in this video and Patient Information available on GOMEKLI.com.

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Support with SpringWorks CareConnections®

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Just getting started on GOMEKLI? In this video, we’ll explain how SpringWorks CareConnections can provide support throughout your treatment.

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The SpringWorks CareConnections logo.

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SpringWorks CareConnections is a free, personalized patient support program for people taking GOMEKLI. The program is available throughout your treatment journey to help you navigate your insurance coverage, answer questions about your treatment, and help you start and stay on track with GOMEKLI.

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Enrollment only takes a few steps, and once you’re signed up one of our Nurse Advocates will give you a call to welcome you to the program. Your Nurse Advocate will be your single point of contact at SpringWorks CareConnections, and can provide you with personalized educational and emotional support. Some of the ways our Nurse Advocates can support you include helping you understand treatment with GOMEKLI, assisting you or your loved one with staying on track and taking the medication, and coordinating with your doctor’s office and pharmacy to make sure you receive GOMEKLI as prescribed. The SpringWorks CareConnections Patient Support Program is not intended to take the place of your healthcare provider, and our team of Nurse Advocates cannot provide medical or clinical advice.

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Terms and conditions apply. Copay program for GOMEKLI and reimbursement for eligible treatment-related costs are subject to annual benefit maximums. To receive reimbursement of eligible treatment-related expenses, an Explanation of Benefits (EOB) form must be submitted, along with copies of receipts for any payments made in full, or your healthcare provider may submit an invoice for services rendered. Full terms and conditions are provided during the enrollment process and are available upon request by contacting SpringWorks CareConnections® at 844-CARES-55 (844-227-3755).

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At SpringWorks, we don’t want concerns about cost or insurance coverage to come between you and your medication. The GOMEKLI Commercial Copay Program may be able to help you save. If you have commercial health insurance, our program could help you pay as little as a $0 copay per 21-day supply of GOMEKLI.

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It may also help with eligible out-of-pocket costs for certain treatment-related tests, exams, or specialty visits during treatment with GOMEKLI.

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Terms and conditions apply. PAP eligibility criteria and annual household income limits apply. Full terms and conditions are provided during the enrollment process and are available upon request by contacting SpringWorks CareConnections® at 844-CARES-55 (844–227–3755).

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And if you’re uninsured, lack coverage for GOMEKLI, or are experiencing financial hardship, ask your Nurse Advocate about the Patient Assistance Program, which may help you obtain GOMEKLI at no cost.

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Enroll in SpringWorks CareConnections® now!

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If you’re ready to start taking advantage of the support offered by SpringWorks CareConnections, you can enroll now by heading to the Savings & Support page of the GOMEKLI website and selecting the “Enroll now” button.

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The SpringWorks CareConnections® Patient Support Program is not intended to take the place of your healthcare provider, and our team of Nurse Advocates cannot provide medical or clinical advice.

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At SpringWorks, we want to make sure that everybody taking GOMEKLI has access to support. We can’t wait to meet you and help you stay on track with your GOMEKLI treatment.

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Important Safety Information
Before taking GOMEKLI, tell your healthcare provider about all of your medical conditions, including if you:

• Have eye problems
• Have heart problems
• Are pregnant or plan to become pregnant. GOMEKLI can harm your unborn baby
  Females who are able to become pregnant:
  • Your healthcare provider should check to see if you are pregnant before you begin treatment with GOMEKLI.
  • Use effective birth control (contraception) during treatment with GOMEKLI and for 6 weeks after your last dose.
  • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with GOMEKLI.
  Males with female partners who are able to become pregnant:
  • Use effective birth control (contraception) during treatment with GOMEKLI and for 3 months after your last dose.
  • Tell your healthcare provider right away if your female partner becomes pregnant or thinks she may be pregnant during treatment with GOMEKLI.
• Are breastfeeding or plan to breastfeed. It is not known if GOMEKLI passes into your breastmilk.
  • Do not breastfeed during treatment with GOMEKLI and for 1 week after your last dose.
  • Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I take GOMEKLI?

• Take GOMEKLI exactly as your healthcare provider tells you to take it. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with GOMEKLI if you develop certain side effects.
• Take GOMEKLI twice a day, about 12 hours apart, for 21 days, followed by 7 days off treatment, to complete a 28-day treatment cycle. Your healthcare provider will decide how many treatment cycles are right for you.
• Take GOMEKLI with or without food.
• GOMEKLI comes in two different dosage forms, GOMEKLI capsules and GOMEKLI tablets for oral suspension. Your healthcare provider will decide the dosage form and dose of GOMEKLI that is right for you.
• If you take GOMEKLI capsules: Swallow each capsule whole with drinking water. If more than 1 capsule is required, swallow 1 capsule at a time. Do not open, break or chew the capsules.
• If you take GOMEKLI tablets for oral suspension, either:
  • Swallow each tablet for oral suspension whole with drinking water. If more than 1 tablet is required, swallow 1 tablet at a time.
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  • Disperse the tablets for oral suspension in drinking water to make a liquid (suspension) before you take or give GOMEKLI.
See the “Instructions for Use” that come with your medicine for instructions on how to prepare and take GOMEKLI tablets for oral suspension.
• If you miss a dose of GOMEKLI, skip the missed dose and take your next dose at your regularly scheduled time.
• If you vomit at any time after taking GOMEKLI, do not take an additional dose. Take your next dose at your regularly scheduled time.

What are the possible side effects of GOMEKLI?
GOMEKLI may cause serious side effects, including:

• Eye problems. GOMEKLI may cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment with GOMEKLI. Tell your healthcare provider right away if you get any of the following signs or symptoms of eye problems:
  • Blurred vision
  • Loss of vision
  • Other changes to your vision
• Heart problems. GOMEKLI may lower the amount of blood pumped by your heart, which is common in children during treatment with GOMEKLI and can also be severe. Your healthcare provider will do tests before you start GOMEKLI treatment, every 3 months during your first year of treatment, and then as needed to make sure your heart is working properly. Tell your healthcare provider right away if you get any of the following signs or symptoms of heart problems:
  • Coughing or wheezing
  • Shortness of breath
  • Swelling of your ankles and feet
  • Tiredness
  • Increased heart rate
• Skin problems. Skin rashes are common with GOMEKLI in both adults and children and can also be severe. GOMEKLI can also cause hair loss (alopecia). Tell your healthcare provider if you develop any of the following signs or symptoms of skin problems:
  • Flat skin rash
  • Raised bumps on the skin
  • Skin bumps that look like acne
  • Skin redness
  • Itchy rash
  • Peeling skin

The most common side effects of GOMEKLI in adults include:

• Diarrhea
• Nausea
• Muscle, joint, and bone pain
• Vomiting
• Tiredness

The most common severe abnormal blood tests in adults include an increased enzyme called creatine phosphokinase (CPK).

The most common side effects of GOMEKLI in children include:

• Diarrhea
• Muscle, joint, and bone pain
• Stomach (abdominal) pain
• Vomiting
• Headache
• Skin redness, swelling, or pain around the fingernails or toenails
• Nausea

The most common severe abnormal blood tests in children include decreased white blood cell (neutrophil) counts and increased CPK.

GOMEKLI may cause fertility problems in females, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all of the possible side effects of GOMEKLI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information and Instructions for Use, available on GOMEKLI.com.

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©2025 SpringWorks Therapeutics, Inc. All rights reserved. GOMEKLI and SpringWorks CareConnections are registered trademarks of SpringWorks Therapeutics, Inc. C_GOM_US_0412 11/25

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