Free, personalized support for people taking GOMEKLI (mirdametinib)
Actor portrayal.
SpringWorks CareConnections is a free, personalized patient support program to help you navigate your insurance coverage and answer questions about your treatment
If you have been prescribed GOMEKLI, ask your healthcare provider to help you enroll in the SpringWorks CareConnections Patient Support Program or click on the button below to get started.
Additional support through the GOMEKLI Digital Companion
SpringWorks has partnered with Medisafe, the #1 medication management app, to give people taking GOMEKLI a free resource in the GOMEKLI Digital Companion.
Find support in the palm of your hand with:
- Customized reminders for GOMEKLI and other medications you take so you won’t forget a dose
- Access to GOMEKLI educational content
- Access to the SpringWorks CareConnections patient support program directly through the app*
- Additional treatment tools, including health trackers, Medfriend connection with family and friends, appointment management, and more
*Only available once registered with the SpringWorks CareConnections patient support program, which will provide you with your verification code.
Medisafe is available for IOS and Android.
GOMEKLI Digital Companion
GOMEKLI Digital Companion
A free resource to support you or your loved one throughout GOMEKLI treatment.
Image onscreen:
GOMEKLI (mirdametinib) and Medisafe logos
Text onscreen:
Welcome to the GOMEKLI Digital Companion
Text onscreen:
You have recently been prescribed GOMEKLI (mirdametinib)
Text onscreen:
It’s completely normal to have questions as you start your treatment journey
Text onscreen:
Can I create reminders and get notifications to help me stay on track?
How can I learn more about GOMEKLI (mirdametinib)?
Where can I find more information about my condition?
Are there financial assistance options available, and am I eligible for support?
How can I remember all my upcoming doctor appointments?
How can I prepare for my appointments?
Image onscreen:
The GOMEKLI Digital Companion screens on an iPhone
Text onscreen:
To support you or your loved one’s treatment with GOMEKLI (mirdametinib), SpringWorks Therapeutics has developed the GOMEKLI Digital Companion available on Medisafe, a top-rated medication management app
Text onscreen:
The GOMEKLI Digital Companion:
Supports patients on GOMEKLI (mirdametinib) with medication and refill reminders
Provides access to educational content
Helps facilitate engagement with your Nurse Advocate and the SpringWorks CareConnections™
Text onscreen:
For a personalized experience, enroll in SpringWorks CareConnections™ and receive an invite to the GOMEKLI Digital Companion on Medisafe
Image onscreen:
Text message invite to GOMEKLI Digital Companion on iPhone from SpringWorks CareConnections™
Text onscreen:
Download the Medisafe app
Image onscreen:
Google Play and App store badges. Image of Medisafe app in App Store on an iPhone
Text onscreen:
Enter the code you received from your Nurse Advocate
Text onscreen:
Continue to enroll into the GOMEKLI Digital Companion on Medisafe
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Complete your profile
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Create your account
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Next, add your medication reminders
Don’t forget, you can also track all your medications, vitamins, and supplements with Medisafe.*
*Be sure to inform your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements
Text onscreen:
You are enrolled in the GOMEKLI Digital Companion!
Text onscreen:
The GOMEKLI Digital Companion features a dynamic content feed offering personalized support WHEREVER YOU GO. This can be found in the ‘For You’ tab
Text onscreen:
And can provide updates on your coverage status
Text onscreen:
You can also set reminders to take GOMEKLI (mirdametinib) and receive ongoing encouragement
Text onscreen:
The GOMEKLI Digital Companion features a library of supportive and educational content in the ‘Explore’ tab
Text onscreen:
And educational content about your GOMEKLI (mirdametinib) treatment
Text onscreen:
At the tap of a button, you can request a call from your Nurse Advocate
Text onscreen:
Not enrolled in SpringWorks CareConnections™? Enrolling is simple. Call at 844-CARES-55 (844-227-3755) Monday – Friday, 8AM – 10PM ET
Image onscreen:
SpringWorks CareConnections™ logo
Text onscreen:
Please note that you can access the GOMEKLI Digital Companion without enrolling in SpringWorks CareConnections™. However, for a personalized experience and to unlock additional features, we recommend enrolling in SpringWorks CareConnections™.
Image onscreen:
GOMEKLI (mirdametinib) and Medisafe logos
Text onscreen:
Remember your healthcare provider is your primary source of information. Talk to your healthcare provider if you have any questions about your treatment.
Text onscreen:
If you encounter any issues while enrolling in the GOMEKLI Digital Companion and need technical support, please email programsupport@medisafe.com to connect with a member of the Medisafe Customer Support Team.
©2025 SpringWorks Therapeutics, Inc. All rights reserved. GOMEKLI and SpringWorks CareConnections are trademarks of SpringWorks Therapeutics, Inc. C_GOM_US_0283
GOMEKLI (mirdametinib) and Medisafe logos
Text onscreen:
Welcome to the GOMEKLI Digital Companion
Text onscreen:
You have recently been prescribed GOMEKLI (mirdametinib)
Text onscreen:
It’s completely normal to have questions as you start your treatment journey
Text onscreen:
Can I create reminders and get notifications to help me stay on track?
How can I learn more about GOMEKLI (mirdametinib)?
Where can I find more information about my condition?
Are there financial assistance options available, and am I eligible for support?
How can I remember all my upcoming doctor appointments?
How can I prepare for my appointments?
Image onscreen:
The GOMEKLI Digital Companion screens on an iPhone
Text onscreen:
To support you or your loved one’s treatment with GOMEKLI (mirdametinib), SpringWorks Therapeutics has developed the GOMEKLI Digital Companion available on Medisafe, a top-rated medication management app
Text onscreen:
The GOMEKLI Digital Companion:
Supports patients on GOMEKLI (mirdametinib) with medication and refill reminders
Provides access to educational content
Helps facilitate engagement with your Nurse Advocate and the SpringWorks CareConnections™
Text onscreen:
For a personalized experience, enroll in SpringWorks CareConnections™ and receive an invite to the GOMEKLI Digital Companion on Medisafe
Image onscreen:
Text message invite to GOMEKLI Digital Companion on iPhone from SpringWorks CareConnections™
Text onscreen:
Download the Medisafe app
Image onscreen:
Google Play and App store badges. Image of Medisafe app in App Store on an iPhone
Text onscreen:
Enter the code you received from your Nurse Advocate
Text onscreen:
Continue to enroll into the GOMEKLI Digital Companion on Medisafe
Text onscreen:
Complete your profile
Text onscreen:
Create your account
Text onscreen:
Next, add your medication reminders
Don’t forget, you can also track all your medications, vitamins, and supplements with Medisafe.*
*Be sure to inform your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements
Text onscreen:
You are enrolled in the GOMEKLI Digital Companion!
Text onscreen:
The GOMEKLI Digital Companion features a dynamic content feed offering personalized support WHEREVER YOU GO. This can be found in the ‘For You’ tab
Text onscreen:
And can provide updates on your coverage status
Text onscreen:
You can also set reminders to take GOMEKLI (mirdametinib) and receive ongoing encouragement
Text onscreen:
The GOMEKLI Digital Companion features a library of supportive and educational content in the ‘Explore’ tab
Text onscreen:
And educational content about your GOMEKLI (mirdametinib) treatment
Text onscreen:
At the tap of a button, you can request a call from your Nurse Advocate
Text onscreen:
Not enrolled in SpringWorks CareConnections™? Enrolling is simple. Call at 844-CARES-55 (844-227-3755) Monday – Friday, 8AM – 10PM ET
Image onscreen:
SpringWorks CareConnections™ logo
Text onscreen:
Please note that you can access the GOMEKLI Digital Companion without enrolling in SpringWorks CareConnections™. However, for a personalized experience and to unlock additional features, we recommend enrolling in SpringWorks CareConnections™.
Image onscreen:
GOMEKLI (mirdametinib) and Medisafe logos
Text onscreen:
Remember your healthcare provider is your primary source of information. Talk to your healthcare provider if you have any questions about your treatment.
Text onscreen:
If you encounter any issues while enrolling in the GOMEKLI Digital Companion and need technical support, please email programsupport@medisafe.com to connect with a member of the Medisafe Customer Support Team.
©2025 SpringWorks Therapeutics, Inc. All rights reserved. GOMEKLI and SpringWorks CareConnections are trademarks of SpringWorks Therapeutics, Inc. C_GOM_US_0283
A free resource to support you or your loved one throughout GOMEKLI treatment.
Accessing the GOMEKLI Digital Companion
Follow the steps below to download Medisafe and access the GOMEKLI Digital Companion:
If you’re on a desktop computer, scan the QR code. If you’re on a mobile device, tap the badge that corresponds to your device.
If you’re on a desktop computer, scan the QR code. If you’re on a mobile device, tap the badge that corresponds to your device.
Tap “Get” or “Install” to download the FREE Medisafe app.
Tap “Get” or “Install” to download the FREE Medisafe app.
Open Medisafe, then tap “Get Started”.
- Enrollment to the GOMEKLI Digital Companion should begin automatically. If enrollment does not start, tap “Enter verification code” and enter the following verification code: 6QHY
Open Medisafe, then tap “Get Started”.
- Enrollment to the GOMEKLI Digital Companion should begin automatically. If enrollment does not start, tap “Enter verification code” and enter the following verification code: QNN5
Complete the onboarding steps and access the GOMEKLI Digital Companion.
Complete the onboarding steps and access the GOMEKLI Digital Companion.
For a more custom experience, register with SpringWorks CareConnections to receive a personal verification code.
For a more custom experience, register with SpringWorks CareConnections to receive a personal verification code.
Insurance navigation and financial help
Our team of Nurse Advocates can provide information about financial assistance options, as well as explain your insurance coverage for GOMEKLI.
Commercially insured patients may pay as little as a $0 copay per 21-day supply of GOMEKLI with the Commercial Copay Program.†
The program may also help with eligible out-of-pocket costs for certain treatment-related tests, examinations, and/or specialty visits during treatment with GOMEKLI.
Support may be available through SpringWorks CareConnections to help you save on GOMEKLI.
Call 844-CARES-55
(844-227-3755)
Monday – Friday, 8AM – 10PM ET
for more information
(844-227-3755)
Monday – Friday, 8AM – 10PM ET
for more information
Health insurance support guides
SpringWorks CareConnections has also created guides to help you navigate your insurance coverage, including one specifically aimed at supporting young adults.
†Terms and conditions apply. Copay program for GOMEKLI and reimbursement for eligible treatment-related costs are subject to annual benefit maximums. To receive the reimbursement of eligible treatment-related expenses, an Explanation of Benefits (EOB) form must be submitted, along with copies of receipts for any payments made. Full terms and conditions are provided during the enrollment process and are available upon request by contacting SpringWorks CareConnections at 844-CARES-55 (844-227-3755).
Independent Patient Assistance Foundations
Financial assistance may be available through independent foundations that are not controlled by or otherwise affiliated with SpringWorks Therapeutics. These foundations may be able to assist with copays, premiums, patient education, social services, etc.
SpringWorks Therapeutics does not influence or control the operations of independent patient assistance foundations and cannot guarantee assistance will be provided. Details and eligibility requirements can be found directly on the individual foundation websites.
Explore additional foundations that may be able to help with financial assistance
Personalized educational and emotional support for patients
Our team of Nurse Advocates‡ can provide treatment support as it relates to your condition, as well as ongoing, personalized support no matter where you are in your treatment journey with GOMEKLI.
Whether you are taking GOMEKLI or are living with or caring for a loved one taking GOMEKLI, SpringWorks CareConnections can provide support and encouragement to help you or your loved one stay on track and take the medication as prescribed.
‡The SpringWorks CareConnections Patient Support Program is not intended to take the place of your healthcare provider, and our team of Nurse Advocates cannot provide medical or clinical advice.
Helpful Resources
Living with or caring for someone with NF1-PN can be challenging. Our resources can help you throughout your journey with GOMEKLI.
NF1-PN=neurofibromatosis type 1 with plexiform neurofibromas.
What is GOMEKLI?
GOMEKLI (mirdametinib) is a prescription medicine used to treat adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas (PN) that cause symptoms and cannot be completely removed by surgery.
It is not known if GOMEKLI is safe and effective in children under 2 years of age.
Important Safety Information
Before taking GOMEKLI, tell your healthcare provider about all of your medical conditions, including if you:
- Have eye problems
- Have heart problems
- Are pregnant or plan to become pregnant. GOMEKLI can harm your unborn baby
Females who are able to become pregnant:
- Your healthcare provider should check to see if you are pregnant before you begin treatment with GOMEKLI.
- Use effective birth control (contraception) during treatment with GOMEKLI and for 6 weeks after your last dose.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with GOMEKLI.
Males with female partners who are able to become pregnant:
- Use effective birth control (contraception) during treatment with GOMEKLI and for 3 months after your last dose.
- Tell your healthcare provider right away if your female partner becomes pregnant or thinks she may be pregnant during treatment with GOMEKLI.
- Are breastfeeding or plan to breastfeed. It is not known if GOMEKLI passes into your breastmilk.
- Do not breastfeed during treatment with GOMEKLI and for 1 week after your last dose.
- Talk to your healthcare provider about the best way to feed your baby during this time.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
How should I take GOMEKLI?
- Take GOMEKLI exactly as your healthcare provider tells you to take it. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with GOMEKLI if you develop certain side effects.
- Take GOMEKLI twice a day, about 12 hours apart, for 21 days, followed by 7 days off treatment, to complete a 28-day treatment cycle. Your healthcare provider will decide how many treatment cycles are right for you.
- Take GOMEKLI with or without food.
- GOMEKLI comes in two different dosage forms, GOMEKLI capsules and GOMEKLI tablets for oral suspension. Your healthcare provider will decide the dosage form and dose of GOMEKLI that is right for you.
- If you take GOMEKLI capsules: Swallow each capsule whole with drinking water. If more than 1 capsule is required, swallow 1 capsule at a time. Do not open, break or chew the capsules.
- If you take GOMEKLI tablets for oral suspension, either:
- Swallow each tablet for oral suspension whole with drinking water. If more than 1 tablet is required, swallow 1 tablet at a time.
- Disperse the tablets for oral suspension in drinking water to make a liquid (suspension) before you take or give GOMEKLI.
OR
See the “Instructions for Use” that come with your medicine for instructions on how to prepare and take GOMEKLI tablets for oral suspension.
- If you miss a dose of GOMEKLI, skip the missed dose and take your next dose at your regularly scheduled time.
- If you vomit at any time after taking GOMEKLI, do not take an additional dose. Take your next dose at your regularly scheduled time.
What are the possible side effects of GOMEKLI?
GOMEKLI may cause serious side effects, including:
- Eye problems. GOMEKLI may cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment with GOMEKLI. Tell your healthcare provider right away if you get any of the following signs or symptoms of eye problems:
- Blurred vision
- Loss of vision
- Other changes to your vision
- Heart problems. GOMEKLI may lower the amount of blood pumped by your heart, which is common in children during treatment with GOMEKLI and can also be severe. Your healthcare provider will do tests before you start GOMEKLI treatment, every 3 months during your first year of treatment, and then as needed to make sure your heart is working properly. Tell your healthcare provider right away if you get any of the following signs or symptoms of heart problems:
- Coughing or wheezing
- Shortness of breath
- Swelling of your ankles and feet
- Tiredness
- Increased heart rate
- Skin problems. Skin rashes are common with GOMEKLI in both adults and children and can also be severe. GOMEKLI can also cause hair loss (alopecia). Tell your healthcare provider if you develop any of the following signs or symptoms of skin problems:
- Flat skin rash
- Raised bumps on the skin
- Skin bumps that look like acne
- Skin redness
- Itchy rash
- Peeling skin
The most common side effects of GOMEKLI in adults include:
- Diarrhea
- Nausea
- Muscle, joint, and bone pain
- Vomiting
- Tiredness
The most common severe abnormal blood tests in adults include an increased enzyme called creatine phosphokinase (CPK).
The most common side effects of GOMEKLI in children include:
- Diarrhea
- Muscle, joint, and bone pain
- Stomach (abdominal) pain
- Vomiting
- Headache
- Skin redness, swelling, or pain around the fingernails or toenails
- Nausea
The most common severe abnormal blood tests in children include decreased white blood cell (neutrophil) counts and increased CPK.
GOMEKLI may cause fertility problems in females, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.
These are not all of the possible side effects of GOMEKLI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is GOMEKLI?
GOMEKLI (mirdametinib) is a prescription medicine used to treat adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas (PN) that cause symptoms and cannot be completely removed by surgery.
It is not known if GOMEKLI is safe and effective in children under 2 years of age.
Please click here for full Prescribing Information, including Patient Information and Instructions for Use.
Please click here for full Prescribing Information, including Patient Information and Instructions for Use.