Resources to support you before and throughout NF1-PN treatment with GOMEKLI
Actor portrayal.
Considering GOMEKLI?
The resources below can help you learn more about GOMEKLI and make the most out of conversations with your healthcare provider.
Is GOMEKLI right for me?
Questions to consider when talking to your healthcare provider about treatment.
GOMEKLI patient brochure (adults and children)
Get information on GOMEKLI, including its potential benefits, possible side effects, dosing, and more.
GOMEKLI patient brochure (adults)
See how adults may experience GOMEKLI, the first and only approved treatment for people 18+ with NF1-PN.
NF1-PN=neurofibromatosis type 1 with plexiform neurofibromas.
Getting started on GOMEKLI?
The following resources were designed to prepare you for your journey with GOMEKLI.
Getting started guide
Find helpful information on what to expect from GOMEKLI and the support offered through SpringWorks CareConnections.
Personalized treatment journal
Keep notes on how you’re feeling while taking GOMEKLI to let your care team know how you’re doing.
SpringWorks CareConnections® brochure
A detailed look at free, personalized support from SpringWorks CareConnections.
Staying on track with GOMEKLI
The resources below can support you throughout GOMEKLI treatment.
Staying on track with treatment
Staying on track with treatment
Hear some tips on how to stay engaged in your care and on top of your GOMEKLI treatment over time.
Image onscreen:
Petal shape from GOMEKLI logo appears onscreen, spinning as if the video is loading. Petal shape comes to a stop as full GOMEKLI logo fades in.
Image onscreen:
GOMEKLI logo shrinks and moves to top center of the frame. Indication statement appears.
Text onscreen and voice-over:
GOMEKLI (mirdametinib) is a prescription medicine used to treat adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas (PN) that cause symptoms and cannot be completely removed by surgery.
It is not known if GOMEKLI is safe and effective in children under 2 years of age.
Please see Important Safety Information later in this video and Patient Information available on GOMEKLI.com.
Image onscreen:
Screen fades and the video title appears.
Text onscreen:
Staying on track with treatment
Voice-over:
If you’ve started on GOMEKLI, congratulations! You’ve taken the first step of your new journey.
Image onscreen:
A man taking a GOMEKLI bottle from his medicine cabinet and taking his dose.
Voice-over:
The next step—and this is really important—is staying on track with your treatment. In this video, we’ll share some tips on how to stay engaged in your care and on top of your GOMEKLI treatment over time.
Image onscreen:
A man examining his arm.
Voice-over:
Once you start taking GOMEKLI, it may take some time to know if you’re responding to treatment. While you may not see immediate results, don’t get discouraged—keep taking your medication as prescribed.
Image onscreen:
A calendar, a pillbox, and a cellphone coming out of a tote bag.
Voice-over:
Everyone tracks their treatment progress in different ways, which is why we’ve designed various tools to suit your needs.
Image onscreen:
The SpringWorks CareConnections logo.
Text onscreen:
SpringWorks CareConnections®: a free, personalized patient support program
Voice-over:
Once you start GOMEKLI and enroll in the SpringWorks CareConnections support program, you’ll be sent a GOMEKLI starter kit.
Image onscreen:
The GOMEKLI dosing calendar appears with dates filling in.
Voice-over:
The GOMEKLI starter kit includes a dosing calendar that you can use to keep track of each dose. It’s a small dry-erase board you can hang right on your refrigerator and reuse for each treatment cycle.
Image onscreen:
A woman affixing the calendar to her refrigerator, and her son marks an “x” on one of the dates.
Voice-over:
If you’re caring for a child or adolescent who’s taking GOMEKLI, have them fill out the calendar along with you. Using it together to track their doses is a nice way for you to help them become more engaged and proactive in their treatment.
Image onscreen:
The weekly pillbox showing one of the daily containers with AM and PM icons on top.
Voice-over:
Also included in the GOMEKLI starter kit is a weekly pillbox. The pillbox includes daily containers that are split into AM and PM compartments to hold your morning and nighttime doses. This can be a helpful resource, whether you’re home or on the go, so you don’t forget to take your medication.
Image onscreen:
A finger tapping on a phone screen to download the Medisafe medication management app.
Voice-over:
Another available tool is the GOMEKLI Digital Companion. It’s a free resource for people taking GOMEKLI, available on the Medisafe medication management app. After downloading the Medisafe app and creating a profile, you can set up your GOMEKLI dosing calendar and add medication reminders, so you never miss a dose. You can learn more about the GOMEKLI dosing calendar, pillbox, and Digital Companion in the “Setting up your GOMEKLI dosing calendar” video on GOMEKLI.com.
Image onscreen:
A doctor’s exam room where a man and his doctor are talking.
Voice-over:
Taking GOMEKLI as prescribed by your healthcare provider is critical. It’s also important to stay vigilant with your appointments because even if you’re not experiencing symptoms, regular appointments are the best way for your healthcare provider to properly assess your progress and make sure things are going well.
Image onscreen:
The personalized treatment journal appears.
Voice-over:
The personalized treatment journal can be used to keep notes on how you’re feeling so your care team knows how you’re doing on GOMEKLI. The treatment journal is included in the GOMEKLI starter kit and can also be downloaded on GOMEKLI.com.
Image onscreen:
A man sitting on his couch reviewing his personalized treatment journal.
Voice-over:
If you change healthcare providers, you can always refer back to your journal as a record of your treatment history. Additionally, once you’re enrolled in SpringWorks CareConnections, you’ll have access to one-on-one support from our team of Nurse Advocates.
Image onscreen:
A man sitting at his computer about to click the “Enroll now” button.
Text onscreen:
The SpringWorks CareConnections® Patient Support Program is not intended to take the place of your healthcare provider, and our team of Nurse Advocates cannot provide medical or clinical advice.
Voice-over:
Nurse Advocates serve as a dedicated single point of contact at SpringWorks CareConnections for patients throughout their GOMEKLI treatment.
Image onscreen:
A Nurse Advocate speaking with a man over the phone.
Voice-over:
They can help you stay on track and take your medication, help you plan conversations with your care team, and work with your healthcare provider and pharmacy so you receive GOMEKLI as prescribed, including prescription refill reminders. And don’t forget, the GOMEKLI patient website has a library of resources designed to support you throughout your GOMEKLI treatment.
Image onscreen:
The man grabs his belongings and walks out of the house.
Voice-over:
Remember, NF1-PN is a long-term condition that may require long-term treatment. Staying on track with your care and treatment will give you the best chance of seeing results.
Text onscreen and voice-over:
Important Safety Information
Before taking GOMEKLI, tell your healthcare provider about all of your medical conditions, including if you:
How should I take GOMEKLI?
What are the possible side effects of GOMEKLI?
GOMEKLI may cause serious side effects, including:
The most common side effects of GOMEKLI in adults include:
The most common side effects of GOMEKLI in children include:
GOMEKLI may cause fertility problems in females, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.
These are not all of the possible side effects of GOMEKLI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information and Instructions for Use, available on GOMEKLI.com.
Text onscreen:
©2025 SpringWorks Therapeutics, Inc. All rights reserved. GOMEKLI and SpringWorks CareConnections are registered trademarks of SpringWorks Therapeutics, Inc. All other trademarks and logos are the property of their respective owners. C_GOM_US_0393 11/25
Voice-over:
Thank you for watching. And remember: You’ve got this!
Petal shape from GOMEKLI logo appears onscreen, spinning as if the video is loading. Petal shape comes to a stop as full GOMEKLI logo fades in.
Image onscreen:
GOMEKLI logo shrinks and moves to top center of the frame. Indication statement appears.
Text onscreen and voice-over:
GOMEKLI (mirdametinib) is a prescription medicine used to treat adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas (PN) that cause symptoms and cannot be completely removed by surgery.
It is not known if GOMEKLI is safe and effective in children under 2 years of age.
Please see Important Safety Information later in this video and Patient Information available on GOMEKLI.com.
Image onscreen:
Screen fades and the video title appears.
Text onscreen:
Staying on track with treatment
Voice-over:
If you’ve started on GOMEKLI, congratulations! You’ve taken the first step of your new journey.
Image onscreen:
A man taking a GOMEKLI bottle from his medicine cabinet and taking his dose.
Voice-over:
The next step—and this is really important—is staying on track with your treatment. In this video, we’ll share some tips on how to stay engaged in your care and on top of your GOMEKLI treatment over time.
Image onscreen:
A man examining his arm.
Voice-over:
Once you start taking GOMEKLI, it may take some time to know if you’re responding to treatment. While you may not see immediate results, don’t get discouraged—keep taking your medication as prescribed.
Image onscreen:
A calendar, a pillbox, and a cellphone coming out of a tote bag.
Voice-over:
Everyone tracks their treatment progress in different ways, which is why we’ve designed various tools to suit your needs.
Image onscreen:
The SpringWorks CareConnections logo.
Text onscreen:
SpringWorks CareConnections®: a free, personalized patient support program
Voice-over:
Once you start GOMEKLI and enroll in the SpringWorks CareConnections support program, you’ll be sent a GOMEKLI starter kit.
Image onscreen:
The GOMEKLI dosing calendar appears with dates filling in.
Voice-over:
The GOMEKLI starter kit includes a dosing calendar that you can use to keep track of each dose. It’s a small dry-erase board you can hang right on your refrigerator and reuse for each treatment cycle.
Image onscreen:
A woman affixing the calendar to her refrigerator, and her son marks an “x” on one of the dates.
Voice-over:
If you’re caring for a child or adolescent who’s taking GOMEKLI, have them fill out the calendar along with you. Using it together to track their doses is a nice way for you to help them become more engaged and proactive in their treatment.
Image onscreen:
The weekly pillbox showing one of the daily containers with AM and PM icons on top.
Voice-over:
Also included in the GOMEKLI starter kit is a weekly pillbox. The pillbox includes daily containers that are split into AM and PM compartments to hold your morning and nighttime doses. This can be a helpful resource, whether you’re home or on the go, so you don’t forget to take your medication.
Image onscreen:
A finger tapping on a phone screen to download the Medisafe medication management app.
Voice-over:
Another available tool is the GOMEKLI Digital Companion. It’s a free resource for people taking GOMEKLI, available on the Medisafe medication management app. After downloading the Medisafe app and creating a profile, you can set up your GOMEKLI dosing calendar and add medication reminders, so you never miss a dose. You can learn more about the GOMEKLI dosing calendar, pillbox, and Digital Companion in the “Setting up your GOMEKLI dosing calendar” video on GOMEKLI.com.
Image onscreen:
A doctor’s exam room where a man and his doctor are talking.
Voice-over:
Taking GOMEKLI as prescribed by your healthcare provider is critical. It’s also important to stay vigilant with your appointments because even if you’re not experiencing symptoms, regular appointments are the best way for your healthcare provider to properly assess your progress and make sure things are going well.
Image onscreen:
The personalized treatment journal appears.
Voice-over:
The personalized treatment journal can be used to keep notes on how you’re feeling so your care team knows how you’re doing on GOMEKLI. The treatment journal is included in the GOMEKLI starter kit and can also be downloaded on GOMEKLI.com.
Image onscreen:
A man sitting on his couch reviewing his personalized treatment journal.
Voice-over:
If you change healthcare providers, you can always refer back to your journal as a record of your treatment history. Additionally, once you’re enrolled in SpringWorks CareConnections, you’ll have access to one-on-one support from our team of Nurse Advocates.
Image onscreen:
A man sitting at his computer about to click the “Enroll now” button.
Text onscreen:
The SpringWorks CareConnections® Patient Support Program is not intended to take the place of your healthcare provider, and our team of Nurse Advocates cannot provide medical or clinical advice.
Voice-over:
Nurse Advocates serve as a dedicated single point of contact at SpringWorks CareConnections for patients throughout their GOMEKLI treatment.
Image onscreen:
A Nurse Advocate speaking with a man over the phone.
Voice-over:
They can help you stay on track and take your medication, help you plan conversations with your care team, and work with your healthcare provider and pharmacy so you receive GOMEKLI as prescribed, including prescription refill reminders. And don’t forget, the GOMEKLI patient website has a library of resources designed to support you throughout your GOMEKLI treatment.
Image onscreen:
The man grabs his belongings and walks out of the house.
Voice-over:
Remember, NF1-PN is a long-term condition that may require long-term treatment. Staying on track with your care and treatment will give you the best chance of seeing results.
Text onscreen and voice-over:
Important Safety Information
Before taking GOMEKLI, tell your healthcare provider about all of your medical conditions, including if you:
- Have eye problems
- Have heart problems
-
Are pregnant or plan to become pregnant. GOMEKLI can harm your unborn baby
Females who are able to become pregnant:- Your healthcare provider should check to see if you are pregnant before you begin treatment with GOMEKLI.
- Use effective birth control (contraception) during treatment with GOMEKLI and for 6 weeks after your last dose.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with GOMEKLI.
- Use effective birth control (contraception) during treatment with GOMEKLI and for 3 months after your last dose.
- Tell your healthcare provider right away if your female partner becomes pregnant or thinks she may be pregnant during treatment with GOMEKLI.
-
Are breastfeeding or plan to breastfeed. It is not known if GOMEKLI passes into your breastmilk.
- Do not breastfeed during treatment with GOMEKLI and for 1 week after your last dose.
- Talk to your healthcare provider about the best way to feed your baby during this time.
How should I take GOMEKLI?
- Take GOMEKLI exactly as your healthcare provider tells you to take it. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with GOMEKLI if you develop certain side effects.
- Take GOMEKLI twice a day, about 12 hours apart, for 21 days, followed by 7 days off treatment, to complete a 28-day treatment cycle. Your healthcare provider will decide how many treatment cycles are right for you.
- Take GOMEKLI with or without food.
- GOMEKLI comes in two different dosage forms, GOMEKLI capsules and GOMEKLI tablets for oral suspension. Your healthcare provider will decide the dosage form and dose of GOMEKLI that is right for you.
- If you take GOMEKLI capsules: Swallow each capsule whole with drinking water. If more than 1 capsule is required, swallow 1 capsule at a time. Do not open, break or chew the capsules.
-
If you take GOMEKLI tablets for oral suspension, either:
- Swallow each tablet for oral suspension whole with drinking water. If more than 1 tablet is required, swallow 1 tablet at a time. OR
- Disperse the tablets for oral suspension in drinking water to make a liquid (suspension) before you take or give GOMEKLI.
See the “Instructions for Use” that come with your medicine for instructions on how to prepare and take GOMEKLI tablets for oral suspension.
- If you miss a dose of GOMEKLI, skip the missed dose and take your next dose at your regularly scheduled time.
- If you vomit at any time after taking GOMEKLI, do not take an additional dose. Take your next dose at your regularly scheduled time.
What are the possible side effects of GOMEKLI?
GOMEKLI may cause serious side effects, including:
-
Eye problems. GOMEKLI may cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment with GOMEKLI. Tell your healthcare provider right away if you get any of the following signs or symptoms of eye problems:
- Blurred vision
- Loss of vision
- Other changes to your vision
-
Heart problems. GOMEKLI may lower the amount of blood pumped by your heart, which is common in children during treatment with GOMEKLI and can also be severe. Your healthcare provider will do tests before you start GOMEKLI treatment, every 3 months during your first year of treatment, and then as needed to make sure your heart is working properly. Tell your healthcare provider right away if you get any of the following signs or symptoms of heart problems:
- Coughing or wheezing
- Shortness of breath
- Swelling of your ankles and feet
- Tiredness
- Increased heart rate
-
Skin problems. Skin rashes are common with GOMEKLI in both adults and children and can also be severe. GOMEKLI can also cause hair loss (alopecia). Tell your healthcare provider if you develop any of the following signs or symptoms of skin problems:
- Flat skin rash
- Raised bumps on the skin
- Skin bumps that look like acne
- Skin redness
- Itchy rash
- Peeling skin
The most common side effects of GOMEKLI in adults include:
- Diarrhea
- Nausea
- Muscle, joint, and bone pain
- Vomiting
- Tiredness
The most common side effects of GOMEKLI in children include:
- Diarrhea
- Muscle, joint, and bone pain
- Stomach (abdominal) pain
- Vomiting
- Headache
- Skin redness, swelling, or pain around the fingernails or toenails
- Nausea
GOMEKLI may cause fertility problems in females, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.
These are not all of the possible side effects of GOMEKLI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please see full Prescribing Information, including Patient Information and Instructions for Use, available on GOMEKLI.com.
Text onscreen:
©2025 SpringWorks Therapeutics, Inc. All rights reserved. GOMEKLI and SpringWorks CareConnections are registered trademarks of SpringWorks Therapeutics, Inc. All other trademarks and logos are the property of their respective owners. C_GOM_US_0393 11/25
Voice-over:
Thank you for watching. And remember: You’ve got this!
Hear some tips on how to stay engaged in your care and on top of your GOMEKLI treatment over time.
Download the Medisafe app to access the GOMEKLI Digital Companion
Helpful videos about GOMEKLI
A full library of videos that can help you throughout treatment.
Additional support through the GOMEKLI Digital Companion
SpringWorks has partnered with Medisafe, the #1 medication management app, to give people taking GOMEKLI a free resource: the GOMEKLI Digital Companion.
Find support in the palm of your hand with:
- Customized reminders for GOMEKLI and other medications you take so you won’t forget a dose
- Access to GOMEKLI educational content
- Access to the SpringWorks CareConnections patient support program directly through the app*
- Additional treatment tools, including health trackers, Medfriend connection with family and friends, appointment management, and more
*Only available once registered with the SpringWorks CareConnections patient support program, which will provide you with your verification code.
Medisafe is available for IOS and Android.
GOMEKLI Digital Companion
GOMEKLI Digital Companion
A free resource to support you or your loved one throughout GOMEKLI treatment.
Image onscreen:
GOMEKLI (mirdametinib) and Medisafe logos
Text onscreen:
Welcome to the GOMEKLI Digital Companion
Text onscreen:
You have recently been prescribed GOMEKLI (mirdametinib)
Text onscreen:
It’s completely normal to have questions as you start your treatment journey
Text onscreen:
Can I create reminders and get notifications to help me stay on track?
How can I learn more about GOMEKLI (mirdametinib)?
Where can I find more information about my condition?
Are there financial assistance options available, and am I eligible for support?
How can I remember all my upcoming doctor appointments?
How can I prepare for my appointments?
Image onscreen:
The GOMEKLI Digital Companion screens on an iPhone
Text onscreen:
To support you or your loved one’s treatment with GOMEKLI (mirdametinib), SpringWorks Therapeutics has developed the GOMEKLI Digital Companion available on Medisafe, a top-rated medication management app
Text onscreen:
The GOMEKLI Digital Companion:
Supports patients on GOMEKLI (mirdametinib) with medication and refill reminders
Provides access to educational content
Helps facilitate engagement with your Nurse Advocate and the SpringWorks CareConnections™ team
Text onscreen:
For a personalized experience, enroll in SpringWorks CareConnections™ and receive an invite to the GOMEKLI Digital Companion on Medisafe
Image onscreen:
Text message invite to GOMEKLI Digital Companion on iPhone from SpringWorks CareConnections™
Text onscreen:
Download the Medisafe app
Image onscreen:
Google Play and App store badges. Image of Medisafe app in App Store on an iPhone
Text onscreen:
Enter the code you received from your Nurse Advocate
Text onscreen:
Continue to enroll into the GOMEKLI Digital Companion on Medisafe
Text onscreen:
Complete your profile
Text onscreen:
Create your account
Text onscreen:
Next, add your medication reminders
Don’t forget, you can also track all your medications, vitamins, and supplements with Medisafe.*
*Be sure to inform your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements
Text onscreen:
You are enrolled in the GOMEKLI Digital Companion!
Text onscreen:
The GOMEKLI Digital Companion features a dynamic content feed offering personalized support WHEREVER YOU GO. This can be found in the ‘For You’ tab
Text onscreen:
And can provide updates on your coverage status
Text onscreen:
You can also set reminders to take GOMEKLI (mirdametinib) and receive ongoing encouragement
Text onscreen:
The GOMEKLI Digital Companion features a library of supportive and educational content in the ‘Explore’ tab
Text onscreen:
And educational content about your GOMEKLI (mirdametinib) treatment
Text onscreen:
At the tap of a button, you can request a call from your Nurse Advocate
Text onscreen:
Not enrolled in SpringWorks CareConnections™? Enrolling is simple. Call at 844-CARES-55 (844-227-3755) Monday – Friday, 8AM – 10PM ET
Image onscreen:
SpringWorks CareConnections™ logo
Text onscreen:
Please note that you can access the GOMEKLI Digital Companion without enrolling in SpringWorks CareConnections™. However, for a personalized experience and to unlock additional features, we recommend enrolling in SpringWorks CareConnections™.
Image onscreen:
GOMEKLI (mirdametinib) and Medisafe logos
Text onscreen:
Remember your healthcare provider is your primary source of information. Talk to your healthcare provider if you have any questions about your treatment.
Text onscreen:
If you encounter any issues while enrolling in the GOMEKLI Digital Companion and need technical support, please email programsupport@medisafe.com to connect with a member of the Medisafe Customer Support Team.
©2025 SpringWorks Therapeutics, Inc. All rights reserved. GOMEKLI and SpringWorks CareConnections are trademarks of SpringWorks Therapeutics, Inc. C_GOM_US_0283
GOMEKLI (mirdametinib) and Medisafe logos
Text onscreen:
Welcome to the GOMEKLI Digital Companion
Text onscreen:
You have recently been prescribed GOMEKLI (mirdametinib)
Text onscreen:
It’s completely normal to have questions as you start your treatment journey
Text onscreen:
Can I create reminders and get notifications to help me stay on track?
How can I learn more about GOMEKLI (mirdametinib)?
Where can I find more information about my condition?
Are there financial assistance options available, and am I eligible for support?
How can I remember all my upcoming doctor appointments?
How can I prepare for my appointments?
Image onscreen:
The GOMEKLI Digital Companion screens on an iPhone
Text onscreen:
To support you or your loved one’s treatment with GOMEKLI (mirdametinib), SpringWorks Therapeutics has developed the GOMEKLI Digital Companion available on Medisafe, a top-rated medication management app
Text onscreen:
The GOMEKLI Digital Companion:
Supports patients on GOMEKLI (mirdametinib) with medication and refill reminders
Provides access to educational content
Helps facilitate engagement with your Nurse Advocate and the SpringWorks CareConnections™ team
Text onscreen:
For a personalized experience, enroll in SpringWorks CareConnections™ and receive an invite to the GOMEKLI Digital Companion on Medisafe
Image onscreen:
Text message invite to GOMEKLI Digital Companion on iPhone from SpringWorks CareConnections™
Text onscreen:
Download the Medisafe app
Image onscreen:
Google Play and App store badges. Image of Medisafe app in App Store on an iPhone
Text onscreen:
Enter the code you received from your Nurse Advocate
Text onscreen:
Continue to enroll into the GOMEKLI Digital Companion on Medisafe
Text onscreen:
Complete your profile
Text onscreen:
Create your account
Text onscreen:
Next, add your medication reminders
Don’t forget, you can also track all your medications, vitamins, and supplements with Medisafe.*
*Be sure to inform your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements
Text onscreen:
You are enrolled in the GOMEKLI Digital Companion!
Text onscreen:
The GOMEKLI Digital Companion features a dynamic content feed offering personalized support WHEREVER YOU GO. This can be found in the ‘For You’ tab
Text onscreen:
And can provide updates on your coverage status
Text onscreen:
You can also set reminders to take GOMEKLI (mirdametinib) and receive ongoing encouragement
Text onscreen:
The GOMEKLI Digital Companion features a library of supportive and educational content in the ‘Explore’ tab
Text onscreen:
And educational content about your GOMEKLI (mirdametinib) treatment
Text onscreen:
At the tap of a button, you can request a call from your Nurse Advocate
Text onscreen:
Not enrolled in SpringWorks CareConnections™? Enrolling is simple. Call at 844-CARES-55 (844-227-3755) Monday – Friday, 8AM – 10PM ET
Image onscreen:
SpringWorks CareConnections™ logo
Text onscreen:
Please note that you can access the GOMEKLI Digital Companion without enrolling in SpringWorks CareConnections™. However, for a personalized experience and to unlock additional features, we recommend enrolling in SpringWorks CareConnections™.
Image onscreen:
GOMEKLI (mirdametinib) and Medisafe logos
Text onscreen:
Remember your healthcare provider is your primary source of information. Talk to your healthcare provider if you have any questions about your treatment.
Text onscreen:
If you encounter any issues while enrolling in the GOMEKLI Digital Companion and need technical support, please email programsupport@medisafe.com to connect with a member of the Medisafe Customer Support Team.
©2025 SpringWorks Therapeutics, Inc. All rights reserved. GOMEKLI and SpringWorks CareConnections are trademarks of SpringWorks Therapeutics, Inc. C_GOM_US_0283
A free resource to support you or your loved one throughout GOMEKLI treatment.
How to access the GOMEKLI Digital Companion
Yes, GOMEKLI is the first FDA-approved treatment for both adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have symptomatic plexiform neurofibromas (PN) not amenable to complete resection.1
The efficacy and safety of GOMEKLI were evaluated in both adult and pediatric patients in the phase 2b, single-arm ReNeu study.1,2 See the ReNeu study design.
Follow the steps below to download Medisafe and access the GOMEKLI Digital Companion:
If you’re on a desktop computer, scan the QR code. If you’re on a mobile device, tap the badge that corresponds to your device.
If you’re on a desktop computer, scan the QR code. If you’re on a mobile device, tap the badge that corresponds to your device.
Tap “Get” or “Install” to download the FREE Medisafe app.
Tap “Get” or “Install” to download the FREE Medisafe app.
Open Medisafe, then tap “Get Started”.
- Enrollment to the GOMEKLI Digital Companion should begin automatically. If enrollment does not start, tap “Enter verification code” and enter the following verification code: 6QHY
Open Medisafe, then tap “Get Started”.
- Enrollment to the GOMEKLI Digital Companion should begin automatically. If enrollment does not start, tap “Enter verification code” and enter the following verification code: QNN5
Complete the onboarding steps and access the GOMEKLI Digital Companion.
Complete the onboarding steps and access the GOMEKLI Digital Companion.
For a more custom experience,
register with SpringWorks CareConnections
to receive a personal verification code.
For a more custom experience, register with SpringWorks CareConnections to receive a personal verification code.
Find a doctor
Finding a healthcare provider who is familiar with NF1 is the most important thing you can do for yourself or your loved one. Use this tool to locate an experienced healthcare provider near you.
Healthcare providers in this database may be recognized by the NF Network, or be members of the Children’s Tumor Foundation’s NF Clinic Network, as noted in their profiles.
These websites also feature tools that can help you locate healthcare providers throughout the US who are familiar with NF1.
SpringWorks Therapeutics is providing these independent resources to help patients find an NF1 treater by region, but SpringWorks Therapeutics had no role in their development. Their inclusion on this website does not represent an endorsement or a recommendation from SpringWorks Therapeutics for any center or physician.
Taking GOMEKLI? You're not alone
Connect with someone else on GOMEKLI
The GOMEKLI Patient Mentor Program is a way to connect virtually with someone living with, or caring for someone living with, NF1-PN who may be able to relate to what you are experiencing.
This program is designed for you to have a one-on-one phone call with a GOMEKLI Guide, during which they will share their personal NF1-PN story and talk about their experience on GOMEKLI. When you register for the program, you will have an opportunity to choose specific topics to discuss on the call, including their experience with things like:
- Tracking symptoms
- Managing side effects
- Staying on track with treatment
To be eligible to participate in the program, you must be at least 18 years of age, reside in the United States, and have, or care for someone who has, a valid prescription for GOMEKLI from a healthcare provider licensed in the United States for an FDA-approved indication.
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What is GOMEKLI?
GOMEKLI (mirdametinib) is a prescription medicine used to treat adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cause symptoms and cannot be completely removed by surgery.
It is not known if GOMEKLI is safe and effective in children under 2 years of age.
Important Safety Information
Before taking GOMEKLI, tell your healthcare provider about all of your medical conditions, including if you:
- Have eye problems
- Have heart problems
- Are pregnant or plan to become pregnant. GOMEKLI can harm your unborn baby
Females who are able to become pregnant:
- Your healthcare provider should check to see if you are pregnant before you begin treatment with GOMEKLI.
- Use effective birth control (contraception) during treatment with GOMEKLI and for 6 weeks after your last dose.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with GOMEKLI.
Males with female partners who are able to become pregnant:
- Use effective birth control (contraception) during treatment with GOMEKLI and for 3 months after your last dose.
- Tell your healthcare provider right away if your female partner becomes pregnant or thinks she may be pregnant during treatment with GOMEKLI.
- Are breastfeeding or plan to breastfeed. It is not known if GOMEKLI passes into your breastmilk.
- Do not breastfeed during treatment with GOMEKLI and for 1 week after your last dose.
- Talk to your healthcare provider about the best way to feed your baby during this time.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
How should I take GOMEKLI?
- Take GOMEKLI exactly as your healthcare provider tells you to take it. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with GOMEKLI if you develop certain side effects.
- Take GOMEKLI twice a day, about 12 hours apart, for 21 days, followed by 7 days off treatment, to complete a 28-day treatment cycle. Your healthcare provider will decide how many treatment cycles are right for you.
- Take GOMEKLI with or without food.
- GOMEKLI comes in two different dosage forms, GOMEKLI capsules and GOMEKLI tablets for oral suspension. Your healthcare provider will decide the dosage form and dose of GOMEKLI that is right for you.
- If you take GOMEKLI capsules: Swallow each capsule whole with drinking water. If more than 1 capsule is required, swallow 1 capsule at a time. Do not open, break or chew the capsules.
- If you take GOMEKLI tablets for oral suspension, either:
- Swallow each tablet for oral suspension whole with drinking water. If more than 1 tablet is required, swallow 1 tablet at a time.
- Disperse the tablets for oral suspension in drinking water to make a liquid (suspension) before you take or give GOMEKLI.
OR
See the “Instructions for Use” that come with your medicine for instructions on how to prepare and take GOMEKLI tablets for oral suspension.
- If you miss a dose of GOMEKLI, skip the missed dose and take your next dose at your regularly scheduled time.
- If you vomit at any time after taking GOMEKLI, do not take an additional dose. Take your next dose at your regularly scheduled time.
What are the possible side effects of GOMEKLI?
GOMEKLI may cause serious side effects, including:
- Eye problems. GOMEKLI may cause eye problems that can lead to blindness. Your healthcare provider will check your vision before and during treatment with GOMEKLI. Tell your healthcare provider right away if you get any of the following signs or symptoms of eye problems:
- Blurred vision
- Loss of vision
- Other changes to your vision
- Heart problems. GOMEKLI may lower the amount of blood pumped by your heart, which is common in children during treatment with GOMEKLI and can also be severe. Your healthcare provider will do tests before you start GOMEKLI treatment, every 3 months during your first year of treatment, and then as needed to make sure your heart is working properly. Tell your healthcare provider right away if you get any of the following signs or symptoms of heart problems:
- Coughing or wheezing
- Shortness of breath
- Swelling of your ankles and feet
- Tiredness
- Increased heart rate
- Skin problems. Skin rashes are common with GOMEKLI in both adults and children and can also be severe. GOMEKLI can also cause hair loss (alopecia). Tell your healthcare provider if you develop any of the following signs or symptoms of skin problems:
- Flat skin rash
- Raised bumps on the skin
- Skin bumps that look like acne
- Skin redness
- Itchy rash
- Peeling skin
The most common side effects of GOMEKLI in adults include:
- Diarrhea
- Nausea
- Muscle, joint, and bone pain
- Vomiting
- Tiredness
The most common severe abnormal blood tests in adults include an increased enzyme called creatine phosphokinase (CPK).
The most common side effects of GOMEKLI in children include:
- Diarrhea
- Muscle, joint, and bone pain
- Stomach (abdominal) pain
- Vomiting
- Headache
- Skin redness, swelling, or pain around the fingernails or toenails
- Nausea
The most common severe abnormal blood tests in children include decreased white blood cell (neutrophil) counts and increased CPK.
GOMEKLI may cause fertility problems in females, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.
These are not all of the possible side effects of GOMEKLI. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is GOMEKLI?
GOMEKLI (mirdametinib) is a prescription medicine used to treat adults and children 2 years of age and older with neurofibromatosis type 1 (NF1) who have plexiform neurofibromas that cause symptoms and cannot be completely removed by surgery.
It is not known if GOMEKLI is safe and effective in children under 2 years of age.
Please click here for full Prescribing Information, including Patient Information and Instructions for Use.
Please click here for full Prescribing Information, including Patient Information and Instructions for Use.